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The underlying mechanism is TD-induced impairment of PDHC activity, which causes remodeling of glucose metabolism in the macrophages
The relatively small sample size (28 Down syndrome cases and 37 controls) may have limited our ability to detect smaller differences between groups and perform subgroup analyses
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Ipamorelin, on the other hand, has yet to pass human clinical trials and is typically administered in conjunction with another peptide
Meanwhile, hypoxia-responsive hydrogels containing azobenzene or nitroimidazole moieties undergo bond cleavage under low O, triggering release of oxygen carriers or hypoxia-activated prodrugsoffering a direct countermeasure to the hypoxiaradioresistance axis [209]
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