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The GLP-1-activated neurons in the brain also limit appetite for a while after a large meal (e.g., the thought of eating is unappealing for many hours after pigging out on pizza).[ref] Stress-related appetite suppression: Additionally, the GLP-1 neurons activate during times of acute stress to suppress appetite
It works through two mechanisms: inhibiting the enzyme tyrosinase (which is essential for melanin synthesis) and shifting the melanin production pathway from eumelanin (darker pigment) to pheomelanin (lighter pigment)
GLP-1R binds to ligands to internalize GLP-1R, and can independently reduce TG accumulation in hepatocytes by activating key signaling molecules downstream of insulin receptor substrate 2 (IRS2)
N Engl J Med (2017) 377(13):122839
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