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Within this framework, the roles of different amino acid pathways in the metabolic network can be understood as differential regulation of key nodes, such as TCA cycle anaplerosis, mTOR signaling, redox balance, or methyl donor cycling

Betaine homocysteine methyltransferase (BHMT) uses betaine as a methyl donor to convert homocysteine to methionine in one-carbon metabolism ( Figure 4 )

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