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Collectively, these analyses indicate that effective dual PDE1B/PDE10A inhibitors will require finely tuned physicochemical properties, strong metabolic stability, and minimal efflux liability to achieve sustained brain exposure with adequate selectivity

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The risks need to be weighed carefully, and alternative treatments such as bariatric surgery should be discussed. Gastroparesis, A Rare Side Effect Gaining Attention Gastroparesis is another potentially serious side effect of semaglutide