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Transcriptomic profiling identifies CD8 + T cells in the brain of aged and Alzheimers disease transgenic mice as tissue-resident memory T cells

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Prolonged exposure by inhalation, ingestion, or skin contact heightens these dangers

3.2 Mitochondrial metabolites as immune signaling molecules In HIV infection, mitochondrial dysfunction alters the levels of key metabolic intermediates, converting them from homeostatic signaling molecules into drivers of pathology

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And the researchers noted that the improvement was better for patients who stayed on medication longer