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Semaglutide acts on the pancreas to reduce both pre- and post-prandial blood glucose concentrations in a glucose-dependent manner primarily by increasing insulin production and inhibiting the secretion of glucagon

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3.2.4 O-linked N-acetylglucosamine Increased O-linked N-acetylglucosamine (O-GlcNAc) levels were previously linked to the adverse cardiac effects of T2DM, including impaired contractility, calcium handling and abnormal stress response (82)