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These findings highlight the evolving nature of the overdose crisis and suggest the need for region-specific strategies to address differing patterns of substance use and overdose risk

Consequently, current clinical findings should be interpreted with caution

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Many glycolytic intermediates, such as ATP, cAMP, cyclic ADP ribose, nitric oxide (NO), long-chain acyl CoA, and high luminal Ca 2+ concentration, have been shown to sensitize RY receptors (248)

1 It can support the preservation of presynaptic connections and neuronal networks