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It produced the highest weight loss seen in any phase 2 trial, up to 24% at the highest dose

Preclinical research suggests NNMT inhibition may affect fat cell metabolism, insulin sensitivity, body weight, and energy expenditure in animal or cell models

2024;17(3):e202300356

Besides, most antidepressants share common challenges, including a marked therapeutic delay of several weeks, limited bioavailability, poor bloodbrain barrier permeability, and instability in the gastrointestinal tract (Ferrari and Villa, 2017

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Derand R, Montoni A, Bulteau-Pignoux L, Janet T, Moreau B, Muller JM, Becq F