In the analysis that most closely reflects real-world clinical practice, participants taking oral semaglutide lost an average of 13.6% of their starting body weight, compared with just 2.4% in those receiving placebo
GLP-1RAs, as an important class of drugs for the treatment of T2DM, shows significant advantages in blood glucose control, weight loss, cardiovascular protection and kidney benefit (Ussher and Drucker, 2023
The dual mechanism targeting insulin resistance is the theoretical reason this works, and the clinical picture is consistent
Fragmented coverage and uneven program-specific evidence are anticipated to hold back wider use
Thinking about moving from injections to tablets
For prescription fills exceeding a 30 day supply, we assumed supply extended across subsequent months (e.g., a 60-day fill was counted as two months of supply)