semaglutide and tirzepatide. Semaglutide/Tirzepatide: Beyond Weight Loss: Shamsah Amersi, MD: OB-GYNs Wondering about the difference between

Mechanism of Action Pancreas: Increases glucose-dependent insulin secretion, decreases glucagon Brain: Enhances satiety Stomach: Slows gastric emptying Main Indications Type 2 diabetes mellitus Obesity/weight management Cardiovascular risk reduction Common Drugs Exenatide Liraglutide Semaglutide Dulaglutide Tirzepatide (dual GIP/GLP-1 agonist) Key Benefits Significant weight loss Low hypoglycemia risk Cardiovascular protection Major Side Effects Nausea/vomiting (most common) Pancreatitis (rare) Thyroid C-cell tumors (boxed warning) Contraindications Multiple Endocrine Neoplasia type 2 (MEN2) Personal/family history of medullary thyroid carcinoma #Pharmaceuticals #GLP1 #Diabetes #Obesity #Healthcare #Biotech #ClinicalResearch #Endocrinology #MedicalAffairs GLP-1 Analogues: Mechanism, Indications, and Side Effects GLP-1 Analogues : Definition Synthetic versions of the natural hormone GLP-1 (glucagon-like peptide-1) that are resistant to DPP-4 breakdown, providing longer-lasting effects

Placebo-controlled, randomized trial of the addition of once-weekly glucagon-like peptide-1 receptor agonist dulaglutide to titrated daily insulin glargine in patients with type 2 diabetes (AWARD-9)

What symptoms should prompt me to seek immediate medical attention

The Environmental Protection Agency (EPA) reports that indoor air measurements are 100 times more polluted compared to our external environments

This condition, known as non-alcoholic fatty liver disease (NAFLD), is becoming increasingly common, particularly among individuals who are overweight or obese

In contrast, there was no evidence of turnover from the [C-TLL][ S 1 ]/pNPB assay, which signified that the reaction stopped after enzyme acylation