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Phase 3 TRIUMPH-4 demonstrated 28.7% mean weight loss at 68 weeks with the 12 mg dose, confirming the exceptional Phase 2 results (24.2% at 48 weeks

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benefit was preserved in the prespecified subgroup receiving sodium-glucose cotransporter-2 inhibitors (SGLT2i) at baseline, which supports combined GLP-1RA + SGLT2i use as a supported option pursuing complementary pathways [4], [33]