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Semaglutide met all primary endpoints and, if the rest of the study proceeds as expected, is about to be extended

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When comparing historical weight loss results during a 68-week clinical trial of Wegovy vs

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A 2025 study published in Obesity found that GLP1 users lost 7.7% of body weight on semaglutide and 12.4% on tirzepatide after one year, roughly half the weight loss seen in randomized trials

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Even now, the rapidness of the weight loss catches some people off guard, says Amaka Nwubah, MD, a board-certified plastic surgeon in Brentwood, Tennessee

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