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A narrative review concluded that the practice is controversial because there are no standardized dosing protocols and nearly onethird of patients report adverse effects, ranging from mild gastrointestinal symptoms to liver dysfunction and lifethreatening allergic reactions

Rare side effects include nausea or headache

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This is evidenced by the inhibition of their growth in immunodeficient mice following lentivirus-mediated GCLC silencing

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Vitamin C, vitamin E, and multivitamin supplement use and stomach cancer mortality in the Cancer prevention study II cohort