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PLOS ONE, 9 (9), e108178
June 16, 2025
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intravenous L-arginine Arginine may activate N-acetylglutamate synthetase (NAGS), thereby counterbalancing the inhibitor effect of valproic acid metabolites
They are not permanent and need maintenance to sustain
Unadjusted analysis found relatively higher (4 and 5.4% additional) weight loss, HbA1c (0.4% additional) reduction, and fewer gastrointestinal side effects with tirzepatide 10 and 15 mg, respectively, than with semaglutide 2.4 mg [25]
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