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Research has also demonstrated that metformin increases the abundance of Akkermansia muciniphila in the gut, which triggers the transcription of host antioxidant genes, including Nqo1 , Ho-1 , and Gpx4 [17]

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This means they slot naturally into human physiology, which explains both their therapeutic potential and why pharmaceutical companies invest billions developing synthetic versions

May aid in healing of intestinal anastomoses and fistulas, and shows benefits in models of inflammatory bowel disease, Crohns disease, and ulcerative colitis235

Alternatively, a doctor may recommend bariatric surgery or weight loss devices