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Yosef R, Pilpel N, Tokarsky-Amiel R, et al
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Dexpramipexole attenuates white matter injury to facilitate locomotion and motor coordination recovery via reducing ferroptosis after intracerebral hemorrhage
Mechanistically they do not overlap (GLP-1 agonists work through appetite and gastric emptying, this works on adipocyte lipogenesis and NAD+), and the mouse data specifically showed fat loss without reduced food intake, so they are not redundant
Schilling A, Corey R, Leonard M, Eghtesad B
Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate receptor mechanism and biological outcomes
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