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Key risks and interactions to be aware of include: Herbal supplements and hormonal therapies: St John's Wort induces liver enzymes (CYP450 pathway) and can significantly reduce the effectiveness of hormonal contraceptives and other medications, as documented in the BNF and relevant SmPCs

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(source: prnewswire.com) January 2025 : Novo Nordisk reported that semaglutide 7.2 mg resulted in a 20.7% weight reduction in the STEP UP trial, outperforming both semaglutide 2.4 mg and placebo

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