The lowest Phase 2 obesity arm was 1 mg weekly and produced 8.7% weight loss at 48 weeks, but the calculator starts below the trial dose to create a slower adaptation ladder
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doi: 10.1016/j.yexcr.2023.113614 Summary Keywords Tregs, Foxo, AMPK pathway, SGLT2I, GLP1-RAs, inflammation, type 2 diabetes Citation Mazzieri A, Basta G, Calafiore R and Luca G (2023) GLP-1 RAs and SGLT2i: two antidiabetic agents associated with immune and inflammation modulatory properties through the common AMPK pathway
Tip: Eating smaller, protein-rich meals and staying hydrated can significantly reduce GI discomfort
Close monitoring by the primary care physician is important for effective management of these effects
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