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Although large studies such as the SELECT trial provide important safety data, a median follow-up of approximately 40 months is insufficient to capture late-onset oncogenesis
Individuals with a BMI in the overweight or obese range, or those struggling with weight despite diet and exercise, may benefit from medically supervised weight loss injections
See the pattern
Common GI side effects (affecting more than 1 in 10 people) according to the SmPC: Nausea : The most frequent side effect, reported in approximately 44% of patients in clinical trials, usually most pronounced during the first few weeks and with dose increases Diarrhoea : Affects roughly 30% of users, typically mild to moderate and transient Vomiting : Occurs in about 24% of patients, often associated with eating too quickly or consuming large portions Constipation : Reported in approximately 24% of users, which may require dietary modification or occasional laxative use Abdominal pain or discomfort : Affects around 20% of patients, usually described as cramping or bloating Dyspepsia and reflux : Indigestion and heartburn occur in approximately 9% of users Less common but significant GI effects : Delayed gastric emptying : Whilst this is the intended pharmacological effect, in some cases it can cause persistent nausea, vomiting, and inability to tolerate food Pancreatitis : Has been reported in clinical trials and post-marketing
How Do GLP-1 Agonists Regulate Appetite and Blood Sugar
Frequent Digestive Issues on Semaglutide If a patient frequently experiences nausea, vomiting, or diarrhea from semaglutide, they may be at higher risk for potassium depletion
