Cell Biochem Biophys
Minerva Endocrinol (2021) 46:16876
As GLP-1 agonists, they target areas of the brain that help regulate appetite and food intake while also helping to lower blood sugar and slow gastric emptying
Comparison of the tissue distribution of GST T1-1 with that of classes Alpha, Mu and Pi GST in human.326No.Pt 3, (September 1997),837846,0264-6021 99
[8] Those data are important for target biology in neuropathic-pain systems, but they do not establish LanCL1 as the mediator of adipocyte lipolysis, fat oxidation, or body-weight effects
While this is certainly a reasonable concern, we view the FDAs decision on Bydureon as excessive, given the lack of any signal for a cardiovascular safety issue and the amount of data already submitted