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When side effects occur, theyre rare and generally mild such as slightly red stool, considered harmless effects of the pigment itself.11 However, certain groups may want to exercise caution

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Stevens-Johnson Syndrome: An infrequent but unappealing side effect of certain drugs

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Steinert JR, Amal H (2022) The Contribution of an Imbalanced Redox Signalling to Neurological and Neurodegenerative Conditions

The trade-off is that higher water volume can slightly accelerate peptide degradation over the 28-day refrigerated window, though the effect is marginal if stored at 28C consistently