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In animal models of HF, GLP-1R agonists increase myocardial glucose uptake [62], stroke volume and LVEF, accompanied by decreasing LVEDP and systemic vascular resistance [63]

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Heres how they compare, molecule to molecule

[25] Mechanism of action [edit] Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increasing insulin secretion by pancreatic Beta cells

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Tirzepatide achieved an average weight loss of 20.2% compared to 13.7% for semaglutide