Some people starting losing weight in the first 2-4 weeks after starting treatment
Protein first (always) Build the meal around high-quality protein to preserve muscle, slow digestion, and enhance satiety
Although ROS generated under physiological conditions are not harmful, and likely play a signaling role, toxic or pathological conditions that lead to an impairment of mitochondrial function can increase the release of ROS

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An 8-week double-blind randomized placebo-controlled trial in 62 patients with PWS demonstrated an improvement of hyperphagiaevaluated as behavior and severity scores by Dykens Hyperphagia Questionnaireafter Topiramate group versus placebo group, with no effects on BMI [95]
Gastrointestinal side effects, affecting up to 50% of GLP-1 users, significantly reduce treatment adherence