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It is with deep sadness that we share the news of the passing of Joel Habener, MD, an extraordinary physician-scientist, mentor, and beloved member of our Mass General Brigham community whose discoveries transformed the field of endocrinology and the care of millions of patients worldwide

Why Alcohol is Tricky on GLP-1s GLP-1s slow gastric emptyingalcohol may hit you harder and faster Alcohol on an empty stomach is worse on GLP-1s Many users report significantly worsened nausea Alcohol lowers inhibitions (may lead to poor food choices) Empty calories without nutrition If You Choose to Drink Stick to these guidelines: Limit to 1 drink maximum Always drink with food (never on empty stomach) Choose lower-calorie options: Wine (5 oz), light beer, spirits with soda water and lime Avoid: Sugary cocktails, margaritas, pia coladas, multiple drinks Drink slowly (sip over 45-60 minutes) Hydrate: Drink water before, during, and after Monitor your response (if you feel worse, skip alcohol entirely going forward) Best Choices if Drinking Dry wine (red or white): ~120 calories per 5 oz Light beer: ~100 calories per 12 oz Vodka/gin + soda water + lime: ~100 calories Champagne/prosecco: ~90 calories per 4 oz Social Pressure to Drink If you prefer to skip alcohol but feel social pressure: Order sparkling water with lime (looks like a cocktail) Say "I'm taking a break from alcohol" Say "Mixing badly with medication I'm on" Hold a non-alcoholic drink so people don't keep offering Real friends respect your choices

Not only do we check its bioactivity, but we also compare it against other commercially available recombinant proteins

Nausea, vomiting, and gastrointestinal issues are well-documented

Its not a GLP-1 drug

10.1016/S0306-4522(96)00434-4 59 LarsenP