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The clinical consequence ranges from local inflammation through to systemic hypersensitivity and antibody formation
HCG used in the final weeks of a cycle primes the Leydig cells and maintains testicular responsiveness, ensuring they are capable of responding to SERM-stimulated LH production when PCT begins
For the annulus fibrosus (the outer ring of the disc made primarily of collagen), this mechanism may support healing of small tears and prevent further deterioration
Sever et al., 2009
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