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Modulation of Tyrosinase Expression Tyrosinase gene expression, together with Tyrp1 and Typr2, is induced by microphthalmia transcription factor (MITF), which is in turn regulated by signaling pathways, including cAMP/PKA/CREB, RAS/MEK/ERK, and -catenin pathways
Symptomatic improvement often precedes laboratory normalisation
The annual rate of change or slope was then compared between treatments, with the statistical significance given by that for the treatment-by-time interaction term 57
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doi: 10.1186/s12905-021-01184-w
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