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Nat Rev Cardiol
Depletion and other background things as you mention are possible, as well as the B-Vits triggering some detox that has been waiting
Nevertheless, almost all the studies have shown some benefit for OA (Table 1)
A recent review highlighted concerns with IV use, including rare anaphylaxis and potential hepatotoxicity (PMC narrative review)
Their success may offer valuable insights into overcoming the unmet promise of single-target antioxidant therapies
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