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It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)

2022;36(3):e22173

Moreover, repeated administration of PEGylated products may produce PEG antibodies, potentially reducing drug efficacy

Direct increases in collagen mRNA production occur across the effective concentration range of 0.01 to 100 nanomolar

The total radioactivity excretion in mixed bile samples collected between 0 and 72 h was low, and tritium water was primarily detected, accounting for 91.2% (females) and 91.0% (males) of the sample