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5-Amino-1MQ is the lead potent, selective small-molecule inhibitor of NNMT identified to date
It is hydrophilic with a pKa value of 11.5 and predominantly remains as an organic cation at physiological pH (Pentikinen et al., 1979)
Kahn also notes that supplements are not FDA-approved, regulated, or rigorously tested like pharmaceuticals, which raises obvious concerns about purity, dosage, and efficacy
It felt like such a huge relief and a big step toward healing
Some maintain most of their progress
Some people use it experimentally for circadian rhythm support or anti-aging purposes, though these applications remain investigational
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