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Hyperuricemia is a globally prevalent condition, particularly in high- and middle-income countries
Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels
By the end of 2022, tirzepatide had gained substantial market share within the broader GLP-1 receptor agonist class, despite being the newest entrant in this therapeutic category
Over-the-counter stool softeners or osmotic laxatives like polyethylene glycol can be used as needed
Like sleep apnea, increased rates were associated with increased overweight/obesity classes
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