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Prediabetes, generally defined as an A1C of 5.7% or higher, is widely treated as a weight-related comorbidity
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Adipose tissue functions as an active immunological organ in psoriasis, secreting pro-inflammatory adipokines (leptin, resistin, adiponectin dysregulation) and amplifying the IL-17/IL-23 and TNF- axes that drive skin disease
link obesity to an increased risk of treatment failure in PsA [52], particularly with anti-TNF drugs, with obese patients showing a lower probability of achieving and maintaining minimal disease activity (MDA)
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