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2024 Feb 16;446:138739
Some users find they need 5-6mg weekly to maintain dietary control during heavy mass phases
In studies, tirzepatide and retatrutide both showed significant weight loss, with retatrutide demonstrating higher efficacy
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For physique athletes and performance-driven individuals, this SIRT1 pathway activation means more fat burned, more muscle spared, and a higher energy ceiling during both cutting and maintenance phases
If considering a dose reduction for maintenance: Wait until weight has stabilized for at least 4 weeks at your current dose Reduce by one dose step (e.g., 12mg to 8mg), do not jump multiple steps Monitor weight closely for 8 weeks after the reduction If weight begins to increase, return to the previous maintenance dose The phase 3 trials specifically tested 4mg as a maintenance dose, suggesting Lilly sees viability in lower maintenance doses What happens if you stop Weight regain after discontinuing GLP-1 agonists is well documented with semaglutide and tirzepatide
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