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When p53 is absent, DPP4 triggers membrane-associated DPP4-mediated lipid peroxidation through binding to NOX1 (NADPH oxidase 1) and forming the NOX1-DPP4 complex, leading to ferroptosis in CRC cells [81]
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Lilly expects to apply for FDA approval of the new drug, orforglipron, by the end of the year
Tseng et al., 2025)
Retatrutide does it via GLP-1 receptor activation in the gut and CNS
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