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Semaglutide is a class of medication called glucagon-like peptide 1 (GLP-1) approved for the treatment of obesity or overweight adults with at least one weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol
Most cycles run 4 to 12 weeks depending on the goal
As a polyspecific transporter, OCTN1 is capable of transporting a variety of organic cations and zwitterions (e.g., tetraethylammonium, acetylcholine, and ergothioneine) and is also involved in the transport of certain drugs
Novo Nordisk) were FDA approved in 2014 and 2021, respectively, to treat obesity
Several case reports have linked the use of these drugs, mainly exenatide, with the occurrence of acute kidney injury, primarily through hemodynamic derangement due to nausea, vomiting, and diarrhea [28]
Patients using insulin or sulfonylureas alongside Rybelsus may need dose adjustments of these medications to reduce hypoglycaemia risk
