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Even compounds with known intracellular targets, such as the estrogen receptor modulator raloxifene, may protect hair cells by inhibiting aminoglycoside entry, rather than acting via modulation of estrogen signaling (Vlasits et al., 2012)
Collagen and elastin promotion
Nature 392 , 821824
Furthermore, inhibition of SIRT1 promotes inflammatory reactions since SIRT1 inhibits transcription of nuclear factor kappa B (NF-B) which also inhibits SIRT1 activation via activation of microRNA and miR-34a which reduce NAD synthesis (Qian et al
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