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These FDA-approved dosing schedules represent standard protocols, though individual patient circumstances may necessitate modifications under physician guidance

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Elsewhere it describes monitoring as more frequent at first, then every 3 to 6 months once things are stable

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10.1074/jbc.M112.423137 J

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Allergy or Mast-Cell Histamine Release Hives, itching, swelling, wheezing, rhinitis or reactions to allergens, temperature, medications or other triggers may reflect immune-cell activation rather than food histamine alone

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The duration and extent of this effect vary by medication type, treatment duration, and individual patient factors

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