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Metformin (for diabetes), proton pump inhibitors (such as omeprazole or esomeprazole), and H2 blockers (such as famotidine) can all reduce B12 absorption over time

B12 Injection Frequency for Deficiency Treatment When treating a vitamin B12 deficiency , how often you get B12 shots matters a lot

Results may vary

Cases of allergic reactions to hydroxocobalamin with tolerance to cyanocobalamin were documented in several instances (1, 2, 3)

Rather than remembering daily pills, patients receive periodic injectionsoften monthly or biweekly depending on individual needsproviding sustained B12 levels between treatments