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One American-based study estimated the additional annual cost associated with obesity in men was US $1152 and in women was US $3613, which given the high prevalence of obesity in the US led to an estimated spending of about $190 billion per year (21% of total healthcare spending) [4]

Since the aim of this pre-planned study was to evaluate direct effects on biological systems induced by the treatment, a per-protocol approach (19) was deemed to more accurately provide an answer than the intention-to-treat approach to this aim

This peptide has also shown benefits in regulating stress in laboratory rats, which are often used to model the peptides effects on neurotransmitter levels and hormone production