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Skin Health and Aging This is perhaps the most popular reason for combining these two
In a continuation of the landmark STEP 1 trial, patients were reviewed a year after stopping semaglutide treatment
While theyre fundamentally similar medications, they differ slightly in their mechanism of action: Wegovy (semaglutide) is a GLP-1 agonist Zepbound (tirzepatide) is a dual agonist: GLP-1 + a glucose-dependent insulinotropic polypeptide (GIP) Both semaglutide and tirzepatide affect the hypothalamus and the hedonic eating centers, the brains center of appetite and cravings
This story was last updated in July 2026
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Tirzepatide (Mounjaro, Zepbound) and liraglutide (Victoza, Saxenda) are two other GLP-1 weight loss medications that can cause constipation
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