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Effectiveness Semaglutide patients typically see about 15% reduction in body weight, while Tirzepatide patients in clinical studies have lost closer to 20% or more

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Bupropion, famous by trade-name Wellbutrin for depression, is a dopamine/norepinephrine reuptake inhibitor, which increases those brain hormones in the areas of the hypothalamus which send signals to reduce appetite, Karl Nadolsky, DO, a clinical endocrinologist and obesity specialist at Holland Hospital and clinical assistant professor of medicine at Michigan State University, told Healthline

However, everyone responds a little differently to GLP-1 medications, sometimes requiring further modification of dosing instructions guidelines to limit side effects or improve effectiveness