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Approximately 40-50% of people are deficient in B12, with rates reaching 50% among those with hypothyroidism
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For a quaternary ammonium salt, the observed mass-spectrometry ion may represent the organic cation rather than the intact salt
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Patients should be informed of the pros and cons of oral versus parenteral therapy, and regardless of the form of treatment, those with pernicious anemia or malabsorption should be reminded of the need for lifelong replacement
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