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Assay-Dependent Potency IC 50 values require test conditions A value of approximately 1.2 M is commonly reported for NNMT inhibition under a specified in-vitro enzyme assay using defined substrate and SAM concentrations

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Cultured human keratinocytes have been suggested as good models to predict dermal irritancy of substances in human subjects 31

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Histone methyltransferases G9a mediated lipid-induced M1 macrophage polarization through negatively regulating CD36