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Semaglutide is a GLP-1 analogue approved as a once-weekly, subcutaneous treatment for T2D [5, 6]
Besides, the GH-IGF-1 axis is incredibly complex
Pharmacologic GLP-1 receptor activation improves glucose homeostasis through glucose-dependent insulin secretion, suppression of inappropriate glucagon secretion, delayed gastric emptying, and reduced appetite
However, it's important to note that the trial did not meet its primary endpoint of fibrosis improvement, and semaglutide is not FDA-approved for the treatment of NASH or metabolic dysfunction-associated steatohepatitis (MASH)
Aggressive Escalation Approaches The standard protocol described above represents the middle ground
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