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doi: 10.3389/FENDO.2021.721135/XML/NLM 7 HolstJJ
Cancer exosomes that carry specific molecules such as, PD-L1, CD63, Caveloin-1, MIA, S100B, Glypican-1, and non-coding RNA to name a few, were shown to stratify patients participating in various clinical trials into responders versus non-responders, healthy controls and disease-free patients versus cancer patients, and/or cancer patients with differing survival outcomes (104, 107, 129133)
Consistent internal conditions
Discrepant findings in humans may be due to the short duration of the studies (on average 35 weeks) and the fact that fractures have not been considered a primary outcome in the studies, but rather, an adverse event [56], (Table 1)
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