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Other contributors may include medications associated with weight gain and endocrine conditions such as hypothyroidism

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Physiological effects mediated by thyroid hormones Thyroid hormones (T3 and T4) are essential for metabolism

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To exert these apparent effects, CJC-1295 appears to interact with specific binding sites on the GHRH receptor protein, leading to conformational changes in the receptor structure and potentially initiating a cascade of molecular events