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143 , 670673.e619 (2023)

Growth hormone stimulates IGF-I synthesis and secretion, which feeds back on the pituitary to inhibit GH secretion (19, 20)

However, semaglutide is unsuitable for individuals with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2

18 Energy Balance When energy intake exceeds overall energy demand, signals from insulin and other metabolic regulators trigger nutrient uptake and storage

However, because its still investigational for broad weight-loss use, dosing frequency and longterm schedule should be determined by a healthcare provider