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Dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme in the pyrimidine de novo synthesis pathway, works alongside GPX4 to inhibit mitochondrial lipid peroxidation
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Orforglipron shorter half-life of 29-49 hours requires daily administration
The July vote did not settle that route debate
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The studys corresponding author is Reshma Ramachandran, MD, MPP, MHS, of Yale University
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