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Orforglipron is a non-peptide
Both the SURPASS program (type 2 diabetes) and SURMOUNT program (obesity) reported nausea, diarrhea, and constipation among the most frequent treatment-emergent adverse events, particularly during dose escalation phases
Patients should not purchase, inject, combine, stop, restart, or transition between weight-loss products without evaluation by a qualified healthcare provider
The upside is that the long-term energy benefits may be even more impactful for this group
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