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The evidence is encouraging but modest, and it points one way: selenium helps most in men who start out short of it

NNMT is an enzyme that, in conditions like obesity, can be overactive, leading to a depletion of nicotinamide needed for NAD+ synthesis

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Andrew Huberman explained the mechanism on Rogan's podcast: BPC-157 acts like a "repair signal" that encourages fibroblasts, the cells that build connective tissue, to migrate to injury sites and start rebuilding