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This is one of the most efficient energy-producing pathways in cells, therefore, high energy demanding tissues, such as heart and kidney, mainly rely on fatty acids utilization (Console et al., 2020)

The speed at which you experience a pick-me-up after a B12 injection can vary depending on a few factors: The Severity of Your Deficiency If you have a mild deficiency, you might feel a difference in energy levels within a few days to a week

Ad libitum access to water and normal chow (RM1, Special Diet Services) or a HFHS diabetogenic diet (AIN-76A, TestDiet) was provided unless otherwise stated

Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency

Friedrichsen M, Breitschaft A, Tadayon S, et al